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Clearsynth is a leading innovator in pharmaceutical reference standards, offering high-quality Reference Standards for Tofacitinib, including both pharmacopeial and non-pharmacopeial impurities, metabolites, stable isotope products, and nitrosamines (N-NO products). Our Tofacitinib impurity reference standards are invaluable for pharmaceutical research, supporting product development, ANDA and DMF submissions, quality control (QC), method validation, and stability studies. They also aid in identifying unknown impurities and assessing genotoxic potential.
Our Tofacitinib-related products undergo thorough characterization and are supplied with detailed Certificates of Analysis (COA) and analytical data that meet regulatory requirements. All supplied products are re-tested at regular intervals to ensure ongoing quality and compliance.

Tofacitinib Related Compounds

Stable Isotopes

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(3R,4S)-Tofacitinib-D3 Stable Isotopes CS-T-96145 1092578-46-5 (Unlabelled) Enquire
N-Nitroso Tofacitinib Amine Impurity D3 Stable Isotopes CS-O-53626 Not Available Enquire
Tofacitinib 13C D2 15N Stable Isotopes CS-O-32721 477600-75-2 (Unlabeled) Enquire
Tofacitinib 13C d3 Stable Isotopes CS-EO-02588 Not Available Enquire
Tofacitinib Citrate-d3 Stable Isotopes CS-EO-00265 540737-29-9 (Unlabelled) Enquire
Tofacitinib D3 Stable Isotopes CS-O-36333 477600-75-2 (Unlabeled) Enquire
Tofacitinib-13C Stable Isotopes CS-O-48660 477600-75-2(Unlabelled) In Stock
Tofacitinib-13C3 Stable Isotopes CS-O-10298 477600-75-2(unlabeled) Enquire
Tofacitinib-13C3,15N Stable Isotopes CS-AI-00211 477600-75-2 (Unlabeled) Enquire
Tofacitinib-13C3,15N Citrate Stable Isotopes CS-O-47447 2256762-71-5 (Freebase) In Stock


API Standards

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Tofacitinib API Standards CS-O-10853 477600-75-2 In Stock
Tofacitinib Citrate API Standards CS-T-51291 540737-29-9 In Stock


Metabolites

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Tofacitinib metabolite-1 Metabolites CS-O-43355 1640971-51-2 Enquire


Impurities

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
(3R,4S)-​Tofacitinib citirate Impurities CS-O-39729 2174011-53-9 Enquire
(3R,4S)-Tofacitinib Impurities CS-T-62103 1092578-46-5 In Stock
(3S,4R)-Tofacitinib Impurities CS-T-62105 1092578-48-7 In Stock
(3S,4S)-Tofacitinib Impurities CS-T-62104 1092578-47-6 Enquire
1,2,3,6,-tetrahydro-1- nitroso4-picoline Impurities CS-O-45591 89600-66-8 Enquire
2,4-Dichloro-7H-Pyrrolo (2,3-d)Pyrimidine Impurities CS-M-42734 90213-66-4 In Stock
3-((3R,4R)-4-methyl-3-(methyl((5R,6S)-2,5,6-trihydroxy-6,7-d... Impurities CS-O-35885 2102039-98-3 Enquire
3-[(3R,4R)-4-methyl-3-[methyl({7H-pyrrolo[2,3-d]pyrimidin-4-... Impurities CS-O-36711 Not Available Enquire
3H-pyrrolo[2,3-d]pyrimidin-4(5H)-one Impurities CS-O-55715 1194710-85-4 Enquire
N-(1-benzyl-4-methylpiperidin-3-yl)-N-methylnitrous amide Impurities CS-O-45589 Not Available Enquire
N,4-dimethyl-1-nitrosopiperidin-3-amine Impurities CS-O-45597 Not Available Enquire
N-Desmethyl Tofacitinib Impurities CS-O-54946 1527525-58-1 Enquire
N-methyl-N-(4-methyl-1-nitrosopiperidin-3-yl)nitrous amide Impurities CS-O-45598 Not Available Enquire
N-methyl-N-(4-methylpiperidin-3-yl)nitrous amide Impurities CS-O-45599 Not Available Enquire
N-methyl-N-(4-methylpyridin-3-yl)nitrous amide Impurities CS-O-46286 Not Available Enquire
N-Nitroso Tofacitinib Amine Impurity Impurities CS-O-40197 Not Available In Stock
Tofacitinib formyl impurity Impurities CS-EO-01760 2227199-28-0 In Stock
Tofacitinib 5 Oxo Impurity Impurities CS-EO-01501 2101951-20-4 Enquire
Tofacitinib Benzyl Impurity Impurities CS-T-88424 477600-73-0 In Stock
Tofacitinib butyl ester impurity Impurities CS-O-43010 Not Available Enquire
Tofacitinib Butyl Impurity Impurities CS-O-54081 2716897-36-6 Enquire
Tofacitinib Citrate Diasteromeric impurity Impurities CS-O-46779 2664002-63-3 Enquire
Tofacitinib Diastereomer Impurities CS-EO-00128 344418-92-4 (Freebase) Enquire
Tofacitinib Diastereomer-1 and 2 Impurities CS-O-33660 2734856-31-4 Enquire
Tofacitinib Dihydro Citricacid salt impurity Impurities CS-O-44098 1809002-40-1 Enquire
Tofacitinib Dihydro Impurity Impurities CS-T-89311 1640972-35-5 In Stock
Tofacitinib Dimer Impurities CS-O-57969 Not Available Enquire
Tofacitinib Hydroxy Impurity Impurities CS-EO-02225 1092578-46-5 Enquire
Tofacitinib Impurity 19 Impurities CS-O-58215 2459302-82-8 Enquire
Tofacitinib Impurity 29 Impurities CS-EO-03056 2459302-85-1 Enquire
Tofacitinib Impurity 57 Impurities CS-EO-03055 2315287-12-6 Enquire
Tofacitinib Impurity 59 Impurities CS-O-58346 32018-56-7 Enquire
Tofacitinib Impurity 6 Impurities CS-EO-01450 2504210-38-0 In Stock
Tofacitinib Impurity 67 Impurities CS-O-57488 2716897-35-5 Enquire
Tofacitinib impurity C Impurities CS-AQ-00034 Not Available Enquire
Tofacitinib impurity F Impurities CS-AQ-00036 Not Available Enquire
Tofacitinib Impurity G Impurities CS-AQ-00037 1354486-07-9 In Stock
Tofacitinib impurity I Impurities CS-AQ-00038 Not Available Enquire
Tofacitinib impurity J Impurities CS-AQ-00039 1431697-80-1 Enquire
Tofacitinib impurity K Impurities CS-AQ-00040 2328165-36-0 In Stock
Tofacitinib Impurity L Impurities CS-AQ-00041 1675248-19-7 In Stock
Tofacitinib impurity N Impurities CS-AQ-00042 1260614-73-0 Enquire
Tofacitinib impurity P Impurities CS-AQ-00044 1252883-90-1 Enquire
Tofacitinib impurity T Impurities CS-AQ-00046 Not Available Enquire
TOFACITINIB IMPURITY TOF-IV Impurities CS-O-49452 2227197-38-6 Enquire
Tofacitinib impurity U Impurities CS-AQ-00047 Not Available Enquire
Tofacitinib impurity V Impurities CS-AQ-00048 1616761-00-2 Enquire
Tofacitinib impurity W Impurities CS-AQ-00049 Not Available Enquire
Tofacitinib impurity X Impurities CS-AQ-00050 2097982-05-1 Enquire
Tofacitinib impurity Z Impurities CS-AQ-00052 477600-76-3 Enquire
Tofacitinib- Keto Impurity Impurities CS-DN-00028 Not Available Enquire
Tofacitinib N- acid Impurity Impurities CS-DN-00027 Not Available Enquire
Tofacitinib N-Descyanoacetyl Hydrochloride Impurity Impurities CS-O-10647 1260590-51-9 In Stock
Tofacitinib N-hydroxy impurity Impurities CS-EO-00807 Not Available Enquire
Tofacitinib Nitroso Impurity 1 Impurities CS-O-45592 Not Available Enquire
Tofacitinib Nitroso Impurity 3 Impurities CS-O-45594 Not Available Enquire
Tofacitinib Nitroso Impurity 4 Impurities CS-O-45595 Not Available Enquire
Tofacitinib Nitroso Impurity 5 Impurities CS-O-45596 Not Available Enquire
Tofacitinib N-Nitroso benzyl intermediate Impurities CS-O-47117 Not Available In Stock
Tofacitinib N-oxide Impurities CS-T-89823 2028267-73-2 Enquire
Tofacitinib Related Compound 26 HCl Impurities CS-P-02224 1206824-85-2 Enquire
Tofacitinib Related Compound 29 Impurities CS-EO-01845 134965-85-8 Enquire
Tofacitinib S,S Isomer Impurities CS-O-33661 2174011-55-1 Enquire


Intermediates

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Tofacitinib Amine intermediate Intermediates CS-O-32365 477600-74-1 In Stock
Tofacitinib Amine intermediate Dihydrochloride Intermediates CS-BX-02592 1655430-59-3 Enquire


Fine Chemicals

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
2-Descyano-2-ethyl Formyl-tofacitinib Fine Chemicals CS-ZH-31805 1675248-18-6 In Stock
Ethyl Cyanoacetate Fine Chemicals CS-T-22644 105-56-6 In Stock


Building Blocks

COMPOUND CATEGORY CAT. No. CAS. No. STOCK STATUS
Tofacitinib intermeduate racemic Building Blocks CS-O-44035 Not Available Enquire